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What Is PEP and How to Control HIV? PEP Is A Medicine you take after you’ve come into contact with an HIV person, and another source, the virus that causes AIDS, to lower your chance of infection. You must start PEP within 3 days (72 hours) after you were exposed to HIV. The sooner you start it, the better. It has little to no effect if you start it 72 hours or more after exposure. PEP can lower your risk of HIV infection by 90% if you take it as your doctor prescribes. Who Might Need PEP? PEP may help: · Folk who think they might have been exposed to HIV Person During Sex · People who have been sexually assaulted · Health care workers who think they’ve been exposed to HIV on the job · Drug users who recently shared needles or other related items If you think y...